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- Title
Precipitating antibodies to rabbit thymus extractable antigens in chronic liver disease: relationship with anti-actin antibodies.
- Authors
Cassani, F.; Fusconi, M.; Bianchi, F. B.; Selleri, L.; Baffoni, Laura; Lenzi, M.; Pisi, E.
- Abstract
Using counterimmunoelectrophoresis (CIE), serum antibodies to rabbit thymus extractable antigens were detected in 15% (38/259) of patients with chronic liver disease (CLD) of various aetiologies and 33% (41/124) of patients with miscellaneous connective tissue diseases (CTD). A remarkable diversity of precipitating systems was apparent among cases with the two classes of disorders. All the five systems found in CLD (XR, XR2, SS-B, XR3, XR4) were associated mostly with immunological hepatic disorders. In the 52 autoimmune hepatitis cases, XR was mainly detected (29%), whereas in the 82 primary biliary cirrhosis patients the whole spectrum of reactivities was represented (XR: 11%, XR2:10%. SS-B and XR3:2% each, XR4:1%). XR proved to be closely associated with smooth muscle antibodies (SMA, detected by indirect immunofluorescence on rat kidney sections) both qualitatively and quantitatively. Since all SMA positive sera with anti-actin specificity (SMAT, SMAG) were XR positive and purified actin could absorb out XR CIE reactivity, the hypothesis is made that a cross-reaction occurs between XR antigen and actin epitope(s).
- Subjects
LIVER diseases; THYMUS; CHRONIC diseases; IMMUNOGLOBULINS; ENDOCRINE glands; ANTIGENS
- Publication
Clinical & Experimental Immunology, 1987, Vol 68, Issue 3, p588
- ISSN
0009-9104
- Publication type
Article