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- Title
Obesity Paradox in Heart Failure with Mildly Reduced Ejection Fraction.
- Authors
Reinhardt, Marielen; Schupp, Tobias; Abumayyaleh, Mohammad; Lau, Felix; Schmitt, Alexander; Abel, Noah; Akin, Muharrem; Rusnak, Jonas; Akin, Ibrahim; Behnes, Michael
- Abstract
The study investigates the prognostic impact of body mass index (BMI) in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF). Background: Limited data regarding the prognostic impact of BMI in patients with HFmrEF is available. Methods: Consecutive patients with HFmrEF (ie, left ventricular ejection fraction 41– 49% and signs and/or symptoms of HF) were retrospectively included at one institution from 2016 to 2022. Risk stratification was performed according to WHO-defined BMI groups. The primary endpoint was all-cause mortality at 30 months (median follow-up). Kaplan-Meier, uni- and multivariable Cox proportional regression analyses were applied for statistics. Results: 1832 consecutive patients with HFmrEF were included with a median BMI of 26.7 kg/m2 (IQR 24.0– 30.8 kg/m2). Patients with lowest BMI (ie, 18.5– 24.9 kg/m2) were associated with highest risk of all-cause mortality at 30 months compared to patients with higher BMI values (40.0% vs 29.0% vs 21.4% vs 20.9%; log rank p = 0.001; HR = 0.721; 95% CI 0.656– 0.793; p = 0.001). Even after multivariable adjustment, higher BMI values were associated with improved survival at 30 months (HR = 0.963; 95% CI 0.943– 0.985; p = 0.001). In contrast, the risk of HF- related rehospitalization at 30 months was not affected by BMI (log rank p = 0.064). Conclusion: In patients hospitalized with HFmrEF, lower BMI was associated with increased risk of all-cause mortality at 30 months, suggesting an obesity paradox in HFmrEF.
- Subjects
HEART failure; OBESITY paradox; VENTRICULAR ejection fraction; HEART failure patients; BODY mass index; MORTALITY
- Publication
Pragmatic & Observational Research, 2024, Vol 15, p31
- ISSN
1179-7266
- Publication type
Article
- DOI
10.2147/POR.S444361