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- Title
Amphiphilic Diblock Copolymers Bearing Poly(Ethylene Glycol) Block: Hydrodynamic Properties in Organic Solvents and Water Micellar Dispersions, Effect of Hydrophobic Block Chemistry on Dispersion Stability and Cytotoxicity.
- Authors
Elistratova, Anastasiia A.; Gubarev, Alexander S.; Lezov, Alexey A.; Vlasov, Petr S.; Solomatina, Anastasia I.; Liao, Yu-Chan; Chou, Pi-Tai; Tunik, Sergey P.; Chelushkin, Pavel S.; Tsvetkov, Nikolai V.
- Abstract
Despite the fact that amphiphilic block copolymers have been studied in detail by various methods both in common solvents and aqueous dispersions, their hydrodynamic description is still incomplete. In this paper, we present a detailed hydrodynamic study of six commercial diblock copolymers featuring the same hydrophilic block (poly(ethylene glycol), PEG; degree of polymerization is ca. 110 ± 25) and the following hydrophobic blocks: polystyrene, PS35-b-PEG115; poly(methyl methacrylate), PMMA55-b-PEG95; poly(1,4-butadyene), PBd90-b-PEG130; polyethylene PE40-b-PEG85; poly(dimethylsiloxane), PDMS15-b-PEG115; and poly(ɛ-caprolactone), PCL45-b-PEG115. The hydrodynamic properties of block copolymers are investigated in both an organic solvent (tetrahydrofuran) and in water micellar dispersions by the combination of static/dynamic light scattering, viscometry, and analytical ultracentrifugation. All the micellar dispersions demonstrate bimodal particle distributions: small compact (hydrodynamic redii, Rh ≤ 17 nm) spherical particles ascribed to "conventional" core–shell polymer micelles and larger particles ascribed to micellar clusters. Hydrodynamic invariants are (2.4 ± 0.4) × 10−10 g cm2 s−2 K−1 mol−1/3 for all types of micelles used in the study. For aqueous micellar dispersions, in view of their potential biomedical applications, their critical micelle concentration values and cytotoxicities are also reported. The investigated micelles are stable towards precipitation, possess low critical micelle concentration values (with the exception of PDMS15-b-PEG115), and demonstrate low toxicity towards Chinese Hamster Ovarian (CHO-K1) cells.
- Subjects
DISPERSION (Chemistry); BLOCK copolymers; ETHYLENE glycol; CRITICAL micelle concentration; ORGANIC solvents; HYDROPHOBIC interactions; DIBLOCK copolymers
- Publication
Polymers (20734360), 2022, Vol 14, Issue 20, p4361
- ISSN
2073-4360
- Publication type
Article
- DOI
10.3390/polym14204361