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- Title
Correlation Between Thymoma and Soluble Interleukin-2 Receptor Expression in a Patient with Good Syndrome.
- Authors
Kitano, Haruka; Yamaguchi, Fumihiro; Atarashi, Kenji; Hiraiwa, Mina; Shiratori, Yo; Onozaki, Shota; Shikama, Yusuke
- Abstract
Good syndrome is a rare condition characterized by the presence of thymoma in combination with adult-onset hypogammaglobulinemia. Immunological features of Good syndrome include various immunodeficiencies accompanied with hypogammaglobulinemia. In patients with thymoma, paraneoplastic syndromes including hypogammaglobulinemia worsen the prognosis. We herein describe a patient with advanced-stage type A thymoma who was effectively treated with chemotherapy and exhibited a parallel decrease in the serum level of soluble interleukin-2 receptor (sIL-2R), which depends on cellular immunity. The present case suggests the efficacy of sIL-2R as a potential prognostic biomarker in a subset of patients with Good syndrome.
- Subjects
THYMOMA; INTERLEUKIN-2; CELLULAR immunity; SYNDROMES; PROGNOSIS; PARANEOPLASTIC syndromes
- Publication
OncoTargets & Therapy, 2021, Vol 14, p5045
- ISSN
1178-6930
- Publication type
Case Study
- DOI
10.2147/OTT.S326193