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- Title
Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy.
- Authors
Shi, Zhi-Zhou; Fan, Ze-Wen; Chen, Yun-Xia; Xie, Xiu-Feng; Jiang, Wen; Wang, Wen-Jun; Qiu, Yun-Tan; Bai, Jie
- Abstract
Ferroptosis is a new form of programmed cell death with characteristic accumulation of reactive oxygen species (ROS) resulting from iron accumulation and lipid peroxidation. Ferroptosis is involved in many diseases, including cancer, and induction of ferroptosis has shown attractive antitumour activities. In this review, we summarize recent findings on the regulatory mechanisms of key regulators of ferroptosis, including the catalytic subunit solute carrier family 7 member 11 (SLC7A11), the glutathione peroxidase 4 (GPX4), p53 and non-coding RNAs, the correlations between ferroptosis and iron homeostasis or autophagy, ferroptosis-inducing agents and nanomaterials and the diagnostic and prognostic value of ferroptosis-associated genes in TCGA data.
- Subjects
APOPTOSIS; CANCER treatment; GLUTATHIONE peroxidase; NON-coding RNA; CARCINOMA
- Publication
OncoTargets & Therapy, 2019, Vol 12, p11291
- ISSN
1178-6930
- Publication type
Article
- DOI
10.2147/OTT.S232852