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- Title
The effect of propofol on intravenous glucose tolerance test in rhesus monkey.
- Authors
Kim, Jong Min; Shin, Jun‐Seop; Yoon, Il Hee; Min, Byoung Hoon; Jeong, Won Young; Lee, Ga Eul; Kim, Min Sun; Kim, Ju Eun; Jang, Jae Yool; Park, Chung‐Gyu
- Abstract
Background Many anesthetics have been shown to impair glucose metabolism and cause hyperglycemia. The aim of this study was to evaluate the effects of propofol on glucose metabolism and insulin secretion during intravenous glucose tolerance test ( IVGTT) in rhesus monkey. Methods Serum cortisol, blood glucose, insulin, and C-peptide concentrations during IVGTT were measured in four rhesus monkeys under either conscious state or propofol anesthesia. Results and Conclusions The levels of serum cortisol significantly increased under conscious condition, whereas these levels remained constant under propofol anesthesia. In propofol group, the levels of serum insulin and C-peptide significantly increased compared with those in conscious group. Accordingly, glucose disposal capacity was significantly improved, and the time to return to basal glucose levels was shortened in propofol group. This study showed that propofol significantly increased insulin and C-peptide, and the corresponding improvement in glucose disposal may be related to reduction of serum cortisol in monkey.
- Subjects
GLUCOSE tolerance tests; GLUCOSE metabolism disorders; PROPOFOL; INTRAVENOUS anesthetics; INSULIN; RHESUS monkeys
- Publication
Journal of Medical Primatology, 2014, Vol 43, Issue 4, p242
- ISSN
0047-2565
- Publication type
Article
- DOI
10.1111/jmp.12128