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A phase I/II trial and pharmacokinetic study of mithramycin in children and adults with refractory Ewing sarcoma and EWS-FLI1 fusion transcript.
Published in:
2017
By:
- Grohar, Patrick;
- Glod, John;
- Peer, Cody;
- Sissung, Tristan;
- Arnaldez, Fernanda;
- Long, Lauren;
- Figg, William;
- Whitcomb, Patricia;
- Helman, Lee;
- Widemann, Brigitte;
- Grohar, Patrick J;
- Peer, Cody J;
- Sissung, Tristan M;
- Arnaldez, Fernanda I;
- Figg, William D;
- Helman, Lee J;
- Widemann, Brigitte C
Publication type:
journal article
Carfilzomib and lenalidomide response related to VEGF and VEGFR2 germline polymorphisms.
Published in:
2017
By:
- Sissung, Tristan;
- Peer, Cody;
- Korde, Neha;
- Mailankody, Sham;
- Kazandjian, Dickran;
- Venzon, David;
- Landgren, Ola;
- Figg, William;
- Sissung, Tristan M;
- Peer, Cody J;
- Venzon, David J;
- Figg, William D
Publication type:
journal article
More than an accessory: implications of type III transforming growth factor-β receptor loss in prostate cancer.
Published in:
BJU International, 2010, v. 105, n. 7, p. 913, doi. 10.1111/j.1464-410X.2009.08999.x
By:
- Ajiboye, Seun;
- Sissung, Tristan M.;
- Sharifi, Nima;
- Figg, William D.
Publication type:
Article
Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival.
Published in:
BJU International, 2008, v. 102, n. 11, p. 1694, doi. 10.1111/j.1464-410X.2008.07913.x
By:
- Gardner, Erin R.;
- Ahlers, Christoph M.;
- Shukla, Suneet;
- Sissung, Tristan M.;
- Ockers, Sandra B.;
- Price, Douglas K.;
- Hamada, Akinobu;
- Robey, Robert W.;
- Steinberg, Seth M.;
- Ambudkar, Suresh V.;
- Dahut, William L.;
- Figg, William D.
Publication type:
Article
A polymorphism in a transporter of testosterone is a determinant of androgen independence in prostate cancer.
Published in:
BJU International, 2008, v. 102, n. 5, p. 617, doi. 10.1111/j.1464-410X.2008.07629.x
By:
- Sharifi, Nima;
- Hamada, Akinobu;
- Sissung, Tristan;
- Danesi, Romano;
- Venzon, David;
- Baum, Caitlin;
- Gulley, James L.;
- Price, Douglas K.;
- Dahut, William L.;
- Figg, William D.
Publication type:
Article
Pre-clinical and clinical evaluation of estramustine, docetaxel and thalidomide combination in androgen-independent prostate cancer.
Published in:
BJU International, 2007, v. 99, n. 5, p. 1047, doi. 10.1111/j.1464-410X.2007.06763.x
By:
- Figg, William D.;
- Li, Haiqing;
- Sissung, Tristan;
- Retter, Avi;
- Wu, Shenhong;
- Gulley, James L.;
- Arlen, Phil;
- Wright, John J.;
- Parnes, Howard;
- Fedenko, Kathy;
- Latham, Lea;
- Steinberg, Seth M.;
- Jones, Elizabeth;
- Chen, Clara;
- Dahut, William
Publication type:
Article
CECs and IL-8 have prognostic and predictive utility in patients with recurrent platinum-sensitive ovarian cancer: biomarker correlates from the randomized phase-2 trial of olaparib and cediranib compared with olaparib in recurrent platinum-sensitive ovarian cancer
Published in:
Frontiers in Oncology, 2015, p. 1, doi. 10.3389/fonc.2015.00123
By:
- Lee, Jung-Min;
- Trepel, Jane B.;
- Choyke, Peter;
- Cao, Liang;
- Sissung, Tristan;
- Houston, Nicole;
- Yu, Minshu;
- Figg, William D.;
- Turkbey, Ismail Baris;
- Steinberg, Seth M.;
- Min-Jung Lee;
- Ivy, S. Percy;
- Liu, Joyce F.;
- Matulonis, Ursula A.;
- Kohn, Elise C.;
- Ford, James M.
Publication type:
Article
Pharmacogenomics with red cells: a model to study protein variants of drug transporter genes.
Published in:
Vox Sanguinis, 2021, v. 116, n. 2, p. 141, doi. 10.1111/vox.12999
By:
- Flegel, Willy Albert;
- Srivastava, Kshitij;
- Sissung, Tristan Michael;
- Goldspiel, Barry Ronald;
- Figg, William Douglas
Publication type:
Article
Comparison of Eight Technologies to Determine Genotype at the UGT1A1 (TA)n Repeat Polymorphism: Potential Clinical Consequences of Genotyping Errors?
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 3, p. 896, doi. 10.3390/ijms21030896
By:
- Sissung, Tristan M.;
- Barbier, Roberto H.;
- Price, Douglas K.;
- Plona, Teri M.;
- Pike, Kristen M.;
- Mellott, Stephanie D.;
- Baugher, Ryan N.;
- Whiteley, Gordon R.;
- Soppet, Daniel R.;
- Venzon, David;
- Berman, Arlene;
- Rajan, Arun;
- Giaccone, Giuseppe;
- Meltzer, Paul;
- Figg, William D.
Publication type:
Article
Estrogen receptor α and aromatase polymorphisms affect risk, prognosis, and therapeutic outcome in men with castration-resistant prostate cancer treated with docetaxel-based therapy.
Published in:
2011
By:
- Sissung, Tristan M;
- Danesi, Romano;
- Kirkland, C Tyler;
- Baum, Caitlin E;
- Ockers, Sandra B;
- Stein, Erica V;
- Venzon, David;
- Price, Douglas K;
- Figg, William D
Publication type:
journal article
Expression of OATP Family Members in Hormone-Related Cancers: Potential Markers of Progression.
Published in:
PLoS ONE, 2011, v. 6, n. 5, p. 1, doi. 10.1371/journal.pone.0020372
By:
- Pressler, Heather;
- Sissung, Tristan M.;
- Venzon, David;
- Price, Douglas K.;
- Figg, William D.
Publication type:
Article
Pharmacogenomics Testing in Phase I Oncology Clinical Trials: Constructive Criticism Is Warranted.
Published in:
Cancers, 2022, v. 14, n. 5, p. 1131, doi. 10.3390/cancers14051131
By:
- Sissung, Tristan M.;
- Figg, William D.
Publication type:
Article
Integrating pharmacogenetic information and clinical decision support into the electronic health record.
Published in:
Journal of the American Medical Informatics Association, 2014, v. 21, n. 3, p. 522, doi. 10.1136/amiajnl-2013-001873
By:
- Goldspiel, Barry R.;
- Flegel, Willy A.;
- Di Patrizio, Gary;
- Sissung, Tristan;
- Adams, Sharon D.;
- Penzak, Scott R.;
- Biesecker, Leslie G.;
- Fleisher, Thomas A.;
- Patel, Jharana J.;
- Herion, David;
- Figg, William D.;
- Lertora, Juan J. L.;
- McKeeby, Jon W.
Publication type:
Article
Precision medicine applications in prostate cancer.
Published in:
Therapeutic Advances in Medical Oncology, 2018, v. 10, n. 1, p. 1, doi. 10.1177/1758835918776920
By:
- McCrea, Edel M.;
- Lee, Daniel K.;
- Sissung, Tristan M.;
- Figg, William D.
Publication type:
Article
Hypertension and hand-foot skin reactions related to VEGFR2 genotype and improved clinical outcome following bevacizumab and sorafenib.
Published in:
Journal of Experimental & Clinical Cancer Research (17569966), 2010, v. 29, p. 95, doi. 10.1186/1756-9966-29-95
By:
- Jain, Lokesh;
- Sissung, Tristan M.;
- Danesi, Romano;
- Kohn, Elise C.;
- Dahut, William L.;
- Kummar, Shivaani;
- Venzon, David;
- Liewehr, David;
- English, Bevin C.;
- Baum, Caitlin E.;
- Yarchoan, Robert;
- Giaccone, Giuseppe;
- Venitz, Jürgen;
- Price, Douglas K.;
- Figg, William D.
Publication type:
Article
Pharmacogenetics of Membrane Transporters: An Update on Current Approaches.
Published in:
Molecular Biotechnology, 2010, v. 44, n. 2, p. 152, doi. 10.1007/s12033-009-9220-6
By:
- Sissung, Tristan;
- Baum, Caitlin;
- Kirkland, C.;
- Gao, Rui;
- Gardner, Erin;
- Figg, William
Publication type:
Article
Alcohol and Aldehyde Dehydrogenases Contribute to Sex-Related Differences in Clearance of Zolpidem in Rats.
Published in:
Frontiers in Pharmacology, 2016, p. 1, doi. 10.3389/fphar.2016.00260
By:
- Peer, Cody J.;
- Strope, Jonathan D.;
- Beedie, Shaunna;
- Ley, Ariel M.;
- Holly, Alesia;
- Calis, Karim;
- Farkas, Ronald;
- Parepally, Jagan;
- Men, Angela;
- Fadiran, Emmanuel O.;
- Scott, Pamela;
- Jenkins, Marjorie;
- Theodore, William H.;
- Sissung, Tristan M.
Publication type:
Article
Histone deacetylase inhibitors modulate K<sub>ATP</sub> subunit transcription in HL-1 cardiomyocytes through effects on cholesterol homeostasis.
Published in:
Frontiers in Pharmacology, 2015, p. 1, doi. 10.3389/fphar.2015.00168
By:
- Fatima, Naheed;
- Cohen, Devin C.;
- Sukumar, Gauthaman;
- Sissung, Tristan M.;
- Schooley Jr., James F.;
- Haigney, Mark C.;
- Claycomb, William C.;
- Cox, Rachel T.;
- Dalgard, Clifton L.;
- Bates, Susan E.;
- Flagg, Thomas P.;
- Hiroshi Hibino;
- Chakraborty, Saikat
Publication type:
Article
A population pharmacokinetic/toxicity model for the reduction of platelets during a 48-h continuous intravenous infusion of the histone deacetylase inhibitor belinostat.
Published in:
2018
By:
- Peer, Cody J.;
- Hall, Oliver M.;
- Sissung, Tristan M.;
- Figg, William D.;
- Piekarz, Richard;
- Balasubramaniam, Sanjeeve;
- Bates, Susan E.
Publication type:
journal article
Pilot study of gadoxetate disodium-enhanced mri for localized and metastatic prostate cancers.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-84960-w
By:
- Lochrin, Sarah E.;
- Turkbey, Baris;
- Gasmi, Billel;
- Schmidt, Keith;
- Strope, Jonathan D.;
- Chau, Cindy H.;
- Sissung, Tristan M.;
- Price, Douglas K.;
- Cordes, Lisa;
- Markolovic, Suzana;
- Wood, Bradford J.;
- Pinto, Peter A.;
- McKinney, Yolanda L.;
- Shih, Joanna H.;
- Levy, Elliot;
- Madan, Ravi;
- Dahut, William;
- Choyke, Peter L.;
- Merino, Maria;
- Figg, William D.
Publication type:
Article
Phase II trial of docetaxel, bevacizumab, lenalidomide and prednisone in patients with metastatic castration-resistant prostate cancer.
Published in:
BJU International, 2016, v. 118, n. 4, p. 590, doi. 10.1111/bju.13412
By:
- Madan, Ravi A.;
- Karzai, Fatima H.;
- Ning, Yang‐Min;
- Adesunloye, Bamidele A.;
- Huang, Xuan;
- Harold, Nancy;
- Couvillon, Anna;
- Chun, Guinevere;
- Cordes, Lisa;
- Sissung, Tristan;
- Beedie, Shaunna L.;
- Dawson, Nancy A.;
- Theoret, Marc R.;
- McLeod, David G.;
- Rosner, Inger;
- Trepel, Jane B.;
- Lee, Min‐Jung;
- Tomita, Yusuke;
- Lee, Sunmin;
- Chen, Clara
Publication type:
Article
Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease.
Published in:
PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0152007
By:
- Nicoli, Elena-Raluca;
- Al Eisa, Nada;
- Cluzeau, Celine V. M.;
- Wassif, Christopher A.;
- Gray, James;
- Burkert, Kathryn R.;
- Smith, David A.;
- Morris, Lauren;
- Cologna, Stephanie M.;
- Peer, Cody J.;
- Sissung, Tristan M.;
- Uscatu, Constantin-Daniel;
- Figg, William D.;
- Pavan, William J.;
- Vite, Charles H.;
- Porter, Forbes D.;
- Platt, Frances M.
Publication type:
Article
Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer.
Published in:
Journal of Clinical Pharmacology, 2016, v. 56, n. 4, p. 461, doi. 10.1002/jcph.625
By:
- Goey, Andrew K. L.;
- Sissung, Tristan M.;
- Peer, Cody J.;
- Trepel, Jane B.;
- Lee, Min‐Jung;
- Tomita, Yusuke;
- Ehrlich, Sheryl;
- Bryla, Christine;
- Balasubramaniam, Sanjeeve;
- Piekarz, Richard;
- Steinberg, Seth M.;
- Bates, Susan E.;
- Figg, William D.
Publication type:
Article
UGT1A1 genotype-dependent dose adjustment of belinostat in patients with advanced cancers using population pharmacokinetic modeling and simulation.
Published in:
Journal of Clinical Pharmacology, 2016, v. 56, n. 4, p. 450, doi. 10.1002/jcph.627
By:
- Peer, Cody J.;
- Goey, Andrew K. L.;
- Sissung, Tristan M.;
- Erlich, Sheryl;
- Lee, Min‐Jung;
- Tomita, Yusuke;
- Trepel, Jane B.;
- Piekarz, Richard;
- Balasubramaniam, Sanjeeve;
- Bates, Susan E.;
- Figg, William D.
Publication type:
Article
Phase 1 study of sorafenib and irinotecan in pediatric patients with relapsed or refractory solid tumors.
Published in:
Pediatric Blood & Cancer, 2021, v. 68, n. 11, p. 1, doi. 10.1002/pbc.29282
By:
- Meany, Holly J.;
- Widemann, Brigitte C.;
- Hinds, Pamela S.;
- Bagatell, Rochelle;
- Shusterman, Suzanne;
- Stern, Emily;
- Jayaprakash, Nalini;
- Peer, Cody J.;
- Figg, William D.;
- Hall, O. Morgan;
- Sissung, Tristan M.;
- Kim, Aerang;
- Fox, Elizabeth;
- London, Wendy B.;
- Rodriguez‐Galindo, Carlos;
- Minturn, Jane E.;
- Dome, Jeffrey S.
Publication type:
Article
Phase 1 trial and pharmacokinetic study of the oral platinum analog satraplatin in children and young adults with refractory solid tumors including brain tumors.
Published in:
Pediatric Blood & Cancer, 2015, v. 62, n. 4, p. 603, doi. 10.1002/pbc.25344
By:
- Akshintala, Srivandana;
- Marcus, Leigh;
- Warren, Katherine E.;
- Murphy, Robert F.;
- Sissung, Tristan M.;
- Srivastava, Anjali;
- Goodspeed, Wendy J.;
- Goodwin, Anne;
- Brewer, Carmen C.;
- Zalewski, Christopher;
- King, Kelly A.;
- Kim, AeRang;
- Figg, William D.;
- Widemann, Brigitte C.
Publication type:
Article
Pharmacogenomics Implementation at the National Institutes of Health Clinical Center.
Published in:
Journal of Clinical Pharmacology, 2017, v. 57, p. S67, doi. 10.1002/jcph.993
By:
- Sissung, Tristan M.;
- McKeeby, Jon W.;
- Patel, Jharana;
- Lertora, Juan J.;
- Kumar, Parag;
- Flegel, Willy A.;
- Adams, Sharon D.;
- Eckes, Ellen J.;
- Mickey, Frank;
- Plona, Teri M.;
- Mellott, Stephanie D.;
- Baugher, Ryan N.;
- Wu, Xiaolin;
- Soppet, Daniel R.;
- Barcus, Mary E.;
- Datta, Vivekananda;
- Pike, Kristen M.;
- DiPatrizio, Gary;
- Figg, William D.;
- Goldspiel, Barry R.
Publication type:
Article
Drug-drug Interactions in Patients with HIV and Cancer in Sub-Saharan Africa.
Published in:
AIDS Reviews, 2021, v. 23, n. 1, p. 13, doi. 10.24875/AIDSRev.20000005
By:
- Strope, Jonathan D.;
- Lochrin, Sarah E.;
- Sissung, Tristan M.;
- Kem, Ravie;
- Chandrasekaran, Prabha;
- Sharon, Elad;
- Price, Douglas K.;
- Uldrick, Thomas S.;
- Yarchoan, Robert;
- Figg, William D.
Publication type:
Article
Pharmacokinetics and pharmacogenomics of ribociclib in black patients with metastatic breast cancer the LEANORA study.
Published in:
NPJ Breast Cancer, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41523-024-00692-w
By:
- Schlam, Ilana;
- Smith, D. Max;
- Peer, Cody;
- Sissung, Tristan;
- Schmidt, Keith T.;
- Tan, Ming;
- Chitalia, Ami;
- Bishopric, Nanette H.;
- Steinberg, Seth;
- Choo-Wosoba, Hyoyoung;
- Napoli, Giulia;
- Gallagher, Christopher;
- Ashai, Nadia;
- Whitaker, Kristen;
- Mainor, Candace;
- Tiwari, Shruti;
- Swanson, Nicole;
- Malloy, Stacy;
- Isaacs, Claudine;
- Figg, William Douglas
Publication type:
Article
Racial Disparities in the Association Between Variants on 8q24 and Prostate Cancer: A Systematic Review and Meta-Analysis.
Published in:
Oncologist, 2012, v. 17, n. 3, p. 312, doi. 10.1634/theoncologist.2011-0315
By:
- TROUTMAN, SARAH M.;
- SISSUNG, TRISTAN M.;
- CROPP, CHERYL D.;
- VENZON, DAVID J.;
- SPENCER, SHAWN D.;
- ADESUNLOYE, BAMIDELE A.;
- HUANG, XUAN;
- KARZAI, FATIMA H.;
- PRICE, DOUGLAS K.;
- FIGG, WILLIAM D.
Publication type:
Article
Reproducibility of pharmacogenetics findings for paclitaxel in a heterogeneous population of patients with lung cancer.
Published in:
PLoS ONE, 2019, v. 14, n. 2, p. 1, doi. 10.1371/journal.pone.0212097
By:
- Sissung, Tristan M.;
- Rajan, Arun;
- Blumenthal, Gideon M.;
- Liewehr, David J.;
- Steinberg, Seth M.;
- Berman, Arlene;
- Giaccone, Giuseppe;
- Figg, William D.
Publication type:
Article
Induction of CYP3A4 by vinblastine: Role of the nuclear receptor NR1I2.
Published in:
2010
By:
- Smith NF;
- Mani S;
- Schuetz EG;
- Yasuda K;
- Sissung TM;
- Bates SE;
- Figg WD;
- Sparreboom A;
- Smith, Nicola F;
- Mani, Sridhar;
- Schuetz, Erin G;
- Yasuda, Kazuto;
- Sissung, Tristan M;
- Bates, Susan E;
- Figg, William D;
- Sparreboom, Alex
Publication type:
journal article
Phase I/Ib study of olaparib and carboplatin in BRCA1 or BRCA2 mutation-associated breast or ovarian cancer with biomarker analyses.
Published in:
2014
By:
- Lee, Jung-Min;
- Hays, John L;
- Annunziata, Christina M;
- Noonan, Anne M;
- Minasian, Lori;
- Zujewski, Jo Anne;
- Yu, Minshu;
- Gordon, Nicolas;
- Ji, Jiuping;
- Sissung, Tristan M;
- Figg, William D;
- Azad, Nilofer;
- Wood, Bradford J;
- Doroshow, James;
- Kohn, Elise C
Publication type:
journal article
Phase l/lb Study of Olaparib and Carboplatin in BRCA1 or BRCA2 Mutation-Associated Breast or Ovarian Cancer With Biomarker Analyses.
Published in:
JNCI: Journal of the National Cancer Institute, 2014, v. 106, n. 6, p. 1, doi. 10.1093/jnci/dju089
By:
- Jung-Min Lee;
- Hays, John L.;
- Annunziata, Christina M.;
- Noonan, Anne M.;
- Minasian, Lori;
- Zujewski, Jo Anne;
- Minshu Yu;
- Gordon, Nicolas;
- Jiuping Ji;
- Sissung, Tristan M.;
- Figg, William D.;
- Azad, Nilofer;
- Wood, Bradford J.;
- Doroshow, James;
- Kohn, Elise C.
Publication type:
Article
Cytochrome 450 1B1 (CYP1B1) polymorphisms associated with response to docetaxel in Castration-Resistant Prostate Cancer (CRPC)patients.
Published in:
BMC Cancer, 2010, v. 10, p. 511, doi. 10.1186/1471-2407-10-511
By:
- Pastina, Ilaria;
- Giovannetti, Elisa;
- Chioni, Aldo;
- Sissung, Tristan M.;
- Crea, Francesco;
- Orlandini, Cinzia;
- Price, Douglas K.;
- Cianci, Claudia;
- Figg, William D.;
- Ricci, Sergio;
- Danesi, Romano
Publication type:
Article

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