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- Title
Upregulation of miR-107 Inhibits Glioma Angiogenesis and VEGF Expression.
- Authors
Chen, Lei; Li, Zong-yang; Xu, Sui-yi; Zhang, Xie-jun; Zhang, Yuan; Luo, Kun; Li, Wei-ping
- Abstract
MicroRNAs can function as oncogenes or tumor suppressors in glioma. Previously, we showed that miR-107 inhibits glioma cell proliferation, migration, and invasion. Since tumor growth and invasion are closely related to angiogenesis, we further examined the role of miR-107 in glioma angiogenesis. In a co-culture of glioma cells and human brain microvascular endothelial cells (HBMVEC), overexpression of miR-107 in glioma cells led to the inhibition of HBMVEC proliferation, migration, and tube formation ability. ELISA, RT-PCR, and western blot assays revealed that upregulation of miR-107 in glioma cells inhibits VEGF expression. Our findings collectively support the critical involvement of miR-107 in glioma cell angiogenesis and highlight its potential as a therapeutic target for glioma.
- Subjects
MICRORNA; ONCOGENES; TUMOR suppressor genes; GLIOMAS; CELL proliferation; CELL migration; TUMOR growth; NEOVASCULARIZATION
- Publication
Cellular & Molecular Neurobiology, 2016, Vol 36, Issue 1, p113
- ISSN
0272-4340
- Publication type
Article
- DOI
10.1007/s10571-015-0225-3