We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Persistently Elevated C-Reactive Protein Level in the First Year of Antiretroviral Therapy, Despite Virologic Suppression, Is Associated With HIV Disease Progression in Resource-Constrained Settings.
- Authors
Shivakoti, Rupak; Wei-Teng Yang; Berendes, Sima; Mwelase, Noluthando; Kanyama, Cecilia; Pillay, Sandy; Samaneka, Wadzanai; Santos, Breno; Poongulali, Selvamuthu; Tripathy, Srikanth; Riviere, Cynthia; Lama, Javier R.; Cardoso, Sandra W.; Sugandhavesa, Patcharaphan; Balagopal, Ashwin; Gupte, Nikhil; Semba, Richard D.; Campbell, Thomas B.; Bollinger, Robert C.; Gupta, Amita
- Abstract
A case-cohort analysis of human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) was performed within a multicountry randomized trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, based on serial measurements of CRP levels, and their association with HIV clinical failure. A persistently elevated CRP level in plasma (defined as ≥ 5 mg/L at both baseline and 24 weeks after ART initiation) was observed in 50 of 205 individuals (24%). A persistently elevated CRP level but not an elevated CRP level only at a single time point was independently associated with increased clinical failure, compared with a persistently low CRP level, despite achievement of virologic suppression. Serial monitoring of CRP levels could identify individuals who are at highest risk of HIV progression and may benefit from future adjunct antiinflammatory therapies.
- Subjects
HIV infection transmission; ANTIRETROVIRAL agents; C-reactive protein; VIROLOGY; HIV; ANTI-inflammatory agents; DISEASE progression; ANTI-HIV agents; COMPARATIVE studies; HIV infections; INFLAMMATION; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; WORLD health; EVALUATION research; RANDOMIZED controlled trials; TREATMENT effectiveness; CASE-control method
- Publication
Journal of Infectious Diseases, 2016, Vol 213, Issue 7, p1074
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiv573