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- Title
Osteopromotion With Synthetic Oligopeptide--Coated Bovine Bone Mineral In Vivo.
- Authors
Park, Jun-Beom; Lee, Jue-Yeon; Park, Ho-Nam; Seol, Yang-Jo; Park, Yoon-Jeong; Rhee, Sang-Hoon; Lee, Sang-Cheol; Kim, Kyoung-Hwa; Kim, Tae-II; Lee, Yong-Moo; Ku, Young; Rhyu, In-Chul; Han, Soo-Boo; Chung, Chong-Pyoung
- Abstract
Background: Recombinant human bone morphogenetic protein (rhBMP)-2 has been shown to stimulate significant regeneration of alveolar bone and cementum in periodontal defects clinically. The aim of this study was to evaluate the osteopromotive effect of oligopeptide domain-coated bovine bone mineral granules in a rabbit calvarial defect model. Methods: The peptide-coated bovine bone was fabricated by incubating the graft material in a solution of oligopeptide domain. The cell attachment and proliferation were measured in vitro. Peptide-coated (test group) or uncoated (control group) bone minerals were implanted into 10-mm calvarial defects in rabbits, and the animals were sacrificed at 1, 2, or 4 weeks post-surgery. Results: The cells grown with peptide-coated bone showed significantly higher proliferation activity at all times compared to cells grown with peptide-uncoated bone mineral. At 2 weeks post-surgery, the control wounds showed a limited amount of osteoid formation in a centripetal pattern around the grafted bone, but the oligopeptide domain-coated grafted bone had formed new bone around the grafted area. At 4 weeks post-surgery, the control sites showed increased new bone formation, but they still showed a significant difference from the peptide-coated bone-implanted sites. Conclusions: At 2 and 4 weeks, accelerated new bone formation was observed within the experimental sites compared to control groups. The use of deproteinized bovine bone combined with a synthetic oligopeptide seems to be a more beneficial material for bone regeneration in the early healing period.
- Subjects
PROTEINS; PERIODONTAL disease; OLIGOPEPTIDES; PEPTIDES; LABORATORY rabbits
- Publication
Journal of Periodontology, 2007, Vol 78, Issue 1, p157
- ISSN
0022-3492
- Publication type
Article
- DOI
10.1902/jop.2007.060200