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- Title
Liver microRNAs: potential mediators and biomarkers for metabolic and cardiovascular disease?
- Authors
Willeit, Peter; Skroblin, Philipp; Kiechl, Stefan; Fernández-Hernando, Carlos; Mayr, Manuel
- Abstract
Recent discoveries have revealed that microRNAs (miRNAs) play a key role in the regulation of gene expression. In this review, we summarize the rapidly evolving knowledge about liver miRNAs (including miR-33, -33*, miR-223, -30c, -144, -148a, -24, -29, and -122) and their link to hepatic lipid metabolism, atherosclerosis and cardiovascular disease, non-alcoholic fatty liver disease, metabolic syndrome, and type-2 diabetes. With regards to its biomarker potential, the main focus is on miR-122 as the most abundant liver miRNA with exquisite tissue specificity. MiR-122 has been proposed to play a central role in the maintenance of lipid and glucose homeostasis and is consistently detectable in serum and plasma. This miRNA may therefore constitute a novel biomarker for cardiovascular and metabolic diseases.
- Publication
European Heart Journal, 2016, Vol 37, Issue 43, p3260
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/ehw146