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- Title
Neoadjuvant endocrine therapy in primary breast cancer: indications and use as a research tool.
- Authors
Chia, Y. H.; Ellis, M. J.; Ma, C. X.
- Abstract
Neoadjuvant endocrine therapy has been increasingly employed in clinical practice to improve surgical options for postmenopausal women with bulky hormone receptor-positive breast cancer. Recent studies indicate that tumour response in this setting may predict long-term outcome of patients on adjuvant endocrine therapy, which argues for its broader application in treating hormone receptor-positive disease. From the research perspective, neoadjuvant endocrine therapy provides a unique opportunity for studies of endocrine responsiveness and the development of novel therapeutic agents.
- Subjects
HORMONE therapy; BREAST cancer patients; ESTROGEN receptors; ADJUVANT treatment of cancer; TREATMENT of diseases in women; GENOMICS; ANTINEOPLASTIC agents; PROTEIN metabolism; BREAST tumors; CELL receptors; COMBINED modality therapy; PREOPERATIVE care; PERIMENOPAUSE; TREATMENT effectiveness
- Publication
British Journal of Cancer, 2010, Vol 103, Issue 6, p759
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/sj.bjc.6605845