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- Title
A combined glucagonoma and VIPoma syndrome. First pathologic and clinical report.
- Authors
Cavallo-Perin, Paolo; de Paoli, Mario; Guiso, Giuseppe; Sapino, Anna; Papotti, Mauro; Coda, Renato; Pagano, Gianfranco; Cavallo-Perin, P; De Paoli, M; Guiso, G; Sapino, A; Papotti, M; Coda, R; Pagano, G
- Abstract
We report a case of pancreatic tumour metastatic to the liver in a patient with insulin-treated diabetes, anaemia, cheilitis, necrolytic migratory erythema, hypokalemia and chronic watery diarrhea, a picture suggesting combined glucagonoma and VIPoma syndromes. Immunocytochemistry of a biopsied hepatic metastatic nodule revealed both glucagon and vasoactive intestinal peptide (VIP) positive cells. Increased plasma glucagon and VIP levels were detected (values of 900 pmol/l and 277 pmol/l respectively). This is the first reported case showing not only immunocytochemical, but also clinical evidence of the combined secretion of these hormones.
- Publication
Cancer (0008543X), 1988, Vol 62, Issue 12, p2576
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19881215)62:12<2576::AID-CNCR2820621221>3.0.CO;2-5