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- Title
Differential var Gene Expression in Children with Malaria and Antidromic Effects on Host Gene Expression.
- Authors
Kalmbach, Yvonne; Rottmann, Matthias; Kombila, Maryvonne; Kremsner, Peter G.; Beck, Hans-Peter; Kun, Jürgen F. J.
- Abstract
Among 62 children with mild malaria, cerebral malaria, or severe malarial anemia, we analyzed the transcription of different var gene types. There was no difference in parasitemia level or body temperature between groups. However, a significantly different expression pattern was observed in children with cerebral malaria, compared with that in patients in the other 2 groups: children with cerebral malaria had lower expression of the upsA subtype but higher expression of the upsB and upsC subtypes. Furthermore, expression of human genes responsive to tumor necrosis factor and hypoxia correlated with distinct ups types.
- Subjects
GENE expression; CEREBRAL malaria; ANEMIA in children; PARASITIC diseases; HUMAN genetics; TUMOR necrosis factors; POLYMERASE chain reaction; CEREBRAL anoxia; BODY temperature; PATIENTS
- Publication
Journal of Infectious Diseases, 2010, Vol 202, Issue 2, p313
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/653586