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- Title
A Substantial Transmission Bottleneck among Newly and Recently HIV-1-Infected Injection Drug Users in St Petersburg, Russia.
- Authors
Masharsky, Alexey E.; Dukhovlinova, Elena N.; Verevochkin, Sergei V.; Toussova, Olga V.; Skochilov, Roman V.; Anderson, Jeffrey A.; Hoffman, Irving; Cohen, Myron S.; Swanstrom, Ronald; Kozlov, Andrei P.
- Abstract
There are limited data on the genetic complexity of human immunodeficiency virus type 1 (HIV-1) after transmission among a cohort of injection drug users (IDUs). We used single-genome amplification of HIV-1 env to determine the genotypic characteristics of virus among IDUs with acute infection in St Petersburg, Russia. Our results indicate that a single variant was transmitted in a majority of cases (9 of 13 participants), which is analogous to what is observed in sexual transmission. These data are most consistent with a genetic bottleneck during transmission by injection drug use that is due to a small inoculum, which most often results in the transmission of a low-complexity viral population.
- Subjects
SAINT Petersburg (Russia); RUSSIA; HIV infection transmission; INTRAVENOUS drug abusers; GENE amplification; POPULATION bottleneck; VIRAL load; HIV-positive persons
- Publication
Journal of Infectious Diseases, 2010, Vol 201, Issue 11, p1697
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/652702