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- Title
Prevalence of Primary HIV-1 Drug Resistance among Recently Infected Adolescents: A Multicenter Adolescent Medicine Trials Network for HIV/AIDS Interventions Study.
- Authors
Viani, Rolando M.; Peralta, Ligia; Aldrovandi, Grace; Kapogiannis, Bill G.; Mitchell, Rick; Spector, Stephen A.; Lie, Yolanda S.; Weidler, Jodi M.; Bates, Michael P.; Liu, Nancy; Wilson, Craig M.
- Abstract
This study examined the prevalence of primary human immunodeficiency type 1 (HIV-1) drug resistance among recently infected youth in the United States. Of the 55 subjects studied, major mutations conferring HIV drug resistance were present in 10 (18%). Eight (15%) had nonnucleoside reverse-transcriptase inhibitor (NNRTI) mutations, with the majority (6) having the K103N mutation; 2 (4%) had nucleoside reverse-transcriptase inhibitor (NRTI) mutations; and 2 (4%) had protease inhibitor (PI) mutations. Phenotypic drug resistance was present in 12 (22%) subjects: 10 (18%) for NNRTIs, 2 (4%) for NRTIs, and 3 (5.5%) for PIs. The prevalence of primary HIV-1 drug resistance, particularly to NNRTIs, in this group of recently infected youth was high.
- Subjects
UNITED States; HIV; DRUG resistance; IMMUNOSUPPRESSION; GENETIC mutation; IMMUNODEFICIENCY
- Publication
Journal of Infectious Diseases, 2006, Vol 194, Issue 11, p1505
- ISSN
0022-1899
- Publication type
Article