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- Title
Reversing Direct Oral Anticoagulants in Acute Intracranial Hemorrhage.
- Authors
Nestor, Melissa A.; Boling, Bryan
- Abstract
Intracerebral hemorrhage is a major source of morbidity and mortality, accounting for 10% of all strokes. Oral anticoagulation therapy, while necessary to prevent thromboembolic complications, increases the risk of intracerebral hemorrhage and can potentially worsen bleeding in cases of acute hemorrhage. Before the introduction of direct oral anticoagulant agents in 2010, warfarin was the only option for oral anticoagulation. These new agents have an improved safety profile compared with warfarin but require different reversal strategies. Anticoagulation reversal in the setting of acute intracerebral hemorrhage is an evolving field. This article covers the most common direct oral anticoagulant medications, various available anticoagulant reversal strategies, and the latest guidelines for anticoagulation reversal in patients with acute intracranial hemorrhage.
- Subjects
VENOUS thrombosis prevention; ANTICOAGULANTS; BENZIMIDAZOLES; BLOOD coagulation factors; CEREBRAL hemorrhage; CHARCOAL; HEMODIALYSIS; MONOCLONAL antibodies; PYRIDINE; RIVAROXABAN
- Publication
Critical Care Nurse, 2019, Vol 39, Issue 3, pe1
- ISSN
0279-5442
- Publication type
Article
- DOI
10.4037/ccn2019160