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- Title
Genotype-guided versus traditional clinical dosing of warfarin in patients of Asian ancestry: a randomized controlled trial.
- Authors
Syn, Nicholas L.; Wong, Andrea Li-Ann; Lee, Soo-Chin; Teoh, Hock-Luen; Yip, James Wei Luen; Seet, Raymond CS; Yeo, Wee Tiong; Kristanto, William; Bee, Ping-Chong; Poon, LM; Marban, Patrick; Wu, Tuck Seng; Winther, Michael D.; Brunham, Liam R.; Soong, Richie; Tai, Bee-Choo; Goh, Boon-Cher; Poon, L M
- Abstract
<bold>Background: </bold>Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved.<bold>Methods: </bold>An open-label, non-inferiority, 1:1 randomized trial was conducted at three academic hospitals in South East Asia, involving 322 ethnically diverse patients newly indicated for warfarin (NCT00700895). Clinical follow-up was 90 days. The primary efficacy measure was the number of dose titrations within the first 2 weeks of therapy, with a mean non-inferiority margin of 0.5 over the first 14 days of therapy.<bold>Results: </bold>Among 322 randomized patients, 269 were evaluable for the primary endpoint. Compared with traditional dosing, the genotype-guided group required fewer dose titrations during the first 2 weeks (1.77 vs. 2.93, difference -1.16, 90% CI -1.48 to -0.84, P < 0.001 for both non-inferiority and superiority). The percentage of time within the therapeutic range over 3 months and median time to stable international normalized ratio (INR) did not differ between the genotype-guided and traditional dosing groups. The frequency of dose titrations (incidence rate ratio 0.76, 95% CI 0.67 to 0.86, P = 0.001), but not frequency of INR measurements, was lower at 1, 2, and 3 months in the genotype-guided group. The proportions of patients who experienced minor or major bleeding, recurrent venous thromboembolism, or out-of-range INR did not differ between both arms. For predicting maintenance doses, the pharmacogenetic algorithm achieved an R2 = 42.4% (P < 0.001) and mean percentage error of -7.4%.<bold>Conclusions: </bold>Among Asian adults commencing warfarin therapy, a pharmacogenetic algorithm meets criteria for both non-inferiority and superiority in reducing dose titrations compared with a traditional dosing approach, and performs well in prediction of actual maintenance doses. These findings imply that clinicians may consider applying a pharmacogenetic algorithm to personalize initial warfarin dosages in Asian patients.<bold>Trial Registration: </bold>ClinicalTrials.gov NCT00700895 . Registered on June 19, 2008.
- Subjects
WARFARIN; RANDOMIZED controlled trials; CLINICAL trials; ANTICOAGULANTS; MEDICAL research
- Publication
BMC Medicine, 2018, Vol 16, Issue 1, pN.PAG
- ISSN
1741-7015
- Publication type
journal article
- DOI
10.1186/s12916-018-1093-8