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- Title
Trends in the prevalence of hepatitis B infection among women giving birth in New South Wales.
- Authors
Deng, Lucy; Reekie, Joanne; Ward, James S.; Hayen, Andrew; Kaldor, John M.; Kong, Marlene; Hunt, Jennifer M.; Liu, Bette
- Abstract
<bold>Objectives: </bold>To evaluate the effect of targeted and catch-up hepatitis B virus (HBV) vaccination programs in New South Wales on HBV prevalence among women giving birth for the first time.<bold>Design: </bold>Observational study linking data from the NSW Perinatal Data Collection for women giving birth during 2000-2012 with HBV notifications in the NSW Notifiable Conditions Information Management System.<bold>Main Outcome Measures: </bold>HBV prevalence in Indigenous Australian, non-Indigenous Australian-born, and overseas-born women giving birth.<bold>Results: </bold>Of 482 944 women who gave birth to their first child, 3383 (0.70%) were linked to an HBV notification. HBV prevalence was 1.95% (95% CI, 1.88-2.02%) among overseas-born women, 0.79% (95% CI, 0.63-0.95%) among Indigenous Australian women, and 0.11% (95% CI, 0.09-0.12%) among non-Indigenous Australian-born women. In Indigenous Australian women, prevalence was significantly lower for those who had been eligible for inclusion in the targeted at-risk newborn or universal school-based vaccination programs (maternal year of birth, 1992-1999: 0.15%) than for those who were not (born ≤ 1981: 1.31%; for trend, P < 0.001). There was no statistically significant downward trend among non-Indigenous Australian-born or overseas-born women. HBV prevalence was higher among Indigenous women residing in regional and remote areas than those in major cities (adjusted odds ratio [aOR], 2.23; 95% CI, 1.40-3.57), but lower for non-Indigenous (aOR, 0.39; 95% CI, 0.28-0.55) and overseas-born women (aOR, 0.61; 95% CI, 0.49-0.77).<bold>Conclusion: </bold>Among women giving birth, there was a significant reduction in HBV prevalence in Indigenous women associated with the introduction of the HBV vaccination program in NSW, although prevalence remains higher than among non-Indigenous Australian-born women, and it also varies by region of residence. Continuing evaluation is needed to ensure that the prevalence of HBV infections continues to fall in Australia.
- Subjects
NEW South Wales; HEPATITIS B vaccines; PERINATAL care; PREVENTION of communicable diseases; HEPATITIS B prevention; PREVENTION of pregnancy complications; COMMUNICABLE disease epidemiology; COMMUNICABLE diseases; HEPATITIS B; HEPATITIS viruses; IMMUNIZATION; INDIGENOUS peoples; MEDICAL protocols; PREGNANCY complications; LOGISTIC regression analysis; ACQUISITION of data; PARITY (Obstetrics); ODDS ratio
- Publication
Medical Journal of Australia, 2017, Vol 206, Issue 7, p301
- ISSN
0025-729X
- Publication type
journal article
- DOI
10.5694/mja16.00823