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- Title
Lactiplantibacillus plantarum P470 Isolated from Fermented Chinese Chives Has the Potential to Improve In Vitro the Intestinal Microbiota and Biological Activity in Feces of Coronary Heart Disease (CHD) Patients.
- Authors
Yang, Lingshuang; Wu, Yuwei; Yang, Juan; Li, Ying; Zhao, Xinyu; Liang, Tingting; Li, Longyan; Jiang, Tong; Zhang, Tiantian; Zhang, Jumei; Zhong, Haojie; Xie, Xinqiang; Wu, Qingping
- Abstract
Traditional fermented foods are known to offer cardiovascular health benefits. However, the potential of fermented Chinese chives (FCC) in reducing coronary heart disease (CHD) remains unclear. This study employed anaerobic fermentation to investigate Lactiplantibacillus plantarum (L. plantarum) P470 from FCC. The results indicated that L. plantarum P470 enhanced hydroxyl radical scavenging and exhibited anti-inflammatory effects on RAW264.7 macrophages in the fecal fermentation supernatant of CHD patients. These effects were attributed to the modulation of gut microbiota and metabolites, including short-chain fatty acids (SCFAs). Specifically, L. plantarum P470 increased the abundance of Bacteroides and Lactobacillus while decreasing Escherichia-Shigella, Enterobacter, Veillonella, Eggerthella, and Helicobacter in CHD patient fecal samples. Furthermore, L. plantarum P470 regulated the biosynthesis of unsaturated fatty acids and linoleic acid metabolism. These findings suggest that L. plantarum P470 from FCC can improve the fecal physiological status in patients with CHD by modulating intestinal microbiota, promoting SCFA production, and regulating lipid metabolism.
- Subjects
CHINA; LIPID metabolism; FECAL analysis; BACTERIAL disease prevention; IN vitro studies; ANTI-inflammatory agents; CORONARY disease; MACROPHAGES; SHORT-chain fatty acids; BACTEROIDES; RESEARCH funding; GUT microbiome; UNSATURATED fatty acids; FERMENTED foods; LINOLEIC acid; METABOLITES; CHIVE; LACTOBACILLUS; PROBIOTICS; BIOLOGICAL assay; CARBOHYDRATE metabolism; PHARMACODYNAMICS
- Publication
Nutrients, 2024, Vol 16, Issue 17, p2945
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16172945