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- Title
Comment on Garvey et al. Association of Baseline Factors With Glycemic Outcomes in GRADE: A Comparative Effectiveness Randomized Clinical Trial. Diabetes Care 2024;47:562–570.
- Authors
Cardoso, Pedro; Young, Katie G.; Hattersley, Andrew T.; Shields, Beverley M.; Jones, Angus G.; Dennis, John M.
- Abstract
The article discusses a recent analysis of the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) randomized controlled trial. The study compares the glycemic outcomes of four commonly used drug classes for type 2 diabetes: sulfonylureas, dipeptidyl peptidase 4 (DPP4) inhibitors, glucagon-like peptide 1 receptor agonists (GLP-1RA), and insulin. The findings indicate that there is differential glycemic response among these drug classes, with sex and age being identified as important factors in treatment effectiveness. The article also addresses some points of clarification regarding the study's findings. Overall, the study contributes to the growing evidence of treatment effect heterogeneity in noninsulin type 2 diabetes therapies.
- Subjects
GLUCAGON-like peptide 1; TREATMENT effect heterogeneity; SODIUM-glucose cotransporter 2 inhibitors; TYPE 2 diabetes; CD26 antigen
- Publication
Diabetes Care, 2024, Vol 47, Issue 9, pe70
- ISSN
0149-5992
- Publication type
Letter
- DOI
10.2337/dc24-0885