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- Title
Weight Status, Autonomic Function, and Systemic Inflammation in Children with Obstructive Sleep Apnea.
- Authors
Chuang, Hai-Hua; Huang, Chung-Guei; Hsu, Jen-Fu; Chuang, Li-Pang; Huang, Yu-Shu; Li, Hsueh-Yu; Lee, Li-Ang
- Abstract
Children with obstructive sleep apnea (OSA) frequently experience chronic low-grade systemic inflammation, with the inflammasome playing a central role in OSA. This cross-sectional study evaluated the relationship between weight status, autonomic function, and systemic inflammation in a cohort of 55 children with OSA, predominantly boys (78%) with an average age of 7.4 ± 2.2 years and an apnea-hypopnea index of 14.12 ± 17.05 events/hour. Measurements were taken of body mass index (BMI), sleep heart-rate variability, morning circulatory levels of interleukin-1β, interleukin-1 receptor antagonist, and interleukin-6, and tumor necrosis factor-α, anthropometry, and polysomnography. Multiple linear regression modeling showed that an apnea-hypopnea index was significantly associated with BMI, the standard deviation of successive differences between normal-to-normal intervals during N3 sleep, and the proportion of normal-to-normal interval pairs differing by more than 50 ms during rapid-eye-movement sleep. A moderated mediation model revealed that interleukin-1 receptor antagonist levels mediated the association between BMI and interleukin-6 levels, with sympathovagal balance during N3 sleep and minimum blood oxygen saturation further moderating these relationships. This study highlights the complex relationships between BMI, polysomnographic parameters, sleep heart-rate-variability metrics, and inflammatory markers in children with OSA, underlining the importance of weight management in this context.
- Subjects
HEART beat; INTERLEUKIN-1 receptors; SLEEP apnea syndromes; OXYGEN saturation; OXYGEN in the blood
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 16, p8951
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25168951