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- Title
Total GestationalWeight Gain Is Explained by Leptin and Body Fat, Regardless of Pre-Pregnancy Body Mass Index and Other Adipokines, in Mexican Adolescents.
- Authors
Chico-Barba, Gabriela; Sámano, Reyna; Martínez-Rojano, Hugo; Morales-Hernández, Rosa María; Barrientos-Galeana, Edgar; Luna-Hidalgo, Andrea; Kaufer-Horwitz, Martha; Obrador, Gregorio T.; Villa-Romero, Antonio Rafael
- Abstract
Pre-pregnancy body mass index (pBMI) is a predictor of gestational weight gain (GWG). However, other factors, such as adipokines and inflammation markers, may also be associated with GWG. The aim of the study was to determine the association of leptin, adiponectin, irisin, and C-reactive protein, with GWG in adolescents. A longitudinal study was conducted from 2018 to 2023 in adolescents with a clinically healthy pregnancy. The assessments included sociodemographic and clinical data, pBMI, percent of body fat, serum concentrations of leptin, adiponectin, irisin, and high-sensitivity C-reactive protein (hsCRP), and total GWG adequacy. Cox regression models were performed, the outcome variables were inadequate and excessive GWG. In 198 participants, being overweight/obesity was marginally associated with a protective effect against inadequate GWG (HR = 0.44, 95%CI = 0.18–1.06), regardless of maternal characteristics and adipokines. Leptin (HR = 1.014, 95%CI = 1.008–1.021), and body fat percent (HR = 1.11, 95%CI = 1.05–1.17) were associated with a higher risk of excessive GWG, independent of other maternal variables such as pBMI, while adiponectin was associated with a lower risk. These findings suggest that, in Mexican adolescents, adipose tissue and its adipokines during pregnancy may play a more significant role in the final GWG than body weight.
- Publication
Nutrients, 2024, Vol 16, Issue 13, p1
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16132147