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- Title
QuantiFERON CMV Test and CMV Serostatus in Lung Transplant: Stratification Risk for Infection, Chronic and Acute Allograft Rejection.
- Authors
Solidoro, Paolo; Sciarrone, Federico; Sidoti, Francesca; Patrucco, Filippo; Zanotto, Elisa; Boffini, Massimo; Rinaldo, Rocco Francesco; Bondi, Alessandro; Albera, Carlo; Curtoni, Antonio; Costa, Cristina
- Abstract
The QuantiFERON CMV (QCMV) test evaluates specific adaptive immune system activity against CMV by measuring IFN-γ released by activated CD8+ T lymphocytes. We aimed to evaluate the QCMV test as a predictive tool for CMV manifestations and acute or chronic lung allograft rejection (AR and CLAD) in lung transplant (LTx) patients. A total of 73 patients were divided into four groups based on donor and recipient (D/R) serology for CMV and QCMV assay: group A low-risk for CMV infection and disease (D−/R−); group B and C at intermediate-risk (R+), group B with non-reactive QCMV and group C with reactive QCMV; group D at high-risk (D+/R−). Group D patients experienced higher viral replication; no differences were observed among R+ patients of groups B and C. D+/R− patients had a higher number of AR events and group C presented a lower incidence of AR. Prevalence of CLAD at 24 months was higher in group B with a higher risk of CLAD development (OR 6.33). The QCMV test allows us to identify R+ non-reactive QCMV population as the most exposed to onset of CLAD. This population had a higher, although non-significant, susceptibility to AR compared to the R+ population with reactive QCMV.
- Subjects
GRAFT rejection; LUNG transplantation; T cells; CYTOMEGALOVIRUS diseases; VIRAL replication; PREDICTIVE tests
- Publication
Viruses (1999-4915), 2024, Vol 16, Issue 8, p1251
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v16081251