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- Title
Metformin-Loaded BSA Nanoparticles in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug.
- Authors
Jose, Pinkybel; Sundar, K.; Anjali, C.; Ravindran, Aswathy
- Abstract
Clinical and experimental data suggest that there is a strong association between type II diabetic mellitus and pancreatic cancer. The present study focuses on exploring the anticancer and antidiabetic properties of metformin-loaded bovine serum albumin nanoparticles (BSA NPs) on (MiaPaCa-2) pancreatic carcinoma cell lines. Albumin nanoparticles were synthesized using coacervation method and the average size of the particles was found to be 97 nm. The particles were stable and showed a spherical morphology with narrow size distribution. We investigated the impact of two stages characterized in type II diabetes mellitus (hyperglycemia and hyperinsulinemia) on the proliferation of MiaPaCa-2 cells and compared the inhibitory effects of bare metformin to that of MET-BSA NPs. Further, different concentrations of insulin and glucose were added along with bare metformin, bare BSA, and metformin encapsulated BSA carrier on MiaPaCa-2 cells to check the strong association between type II diabetes and pancreatic cancer. The results revealed that MET-BSA NPs showed more toxicity when compared with drug and carrier individually.
- Subjects
CANCER treatment; METFORMIN; TYPE 2 diabetes complications; SERUM albumin; NANOPARTICLE synthesis; PHYSIOLOGICAL effects of hypoglycemic agents
- Publication
Cell Biochemistry & Biophysics, 2015, Vol 71, Issue 2, p627
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-014-0242-8