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- Title
Effect of PEGylated Graphene Oxide Nanoparticles on the Metabolism of Jurkat Cells.
- Authors
Timganova, V. P.; Vlasova, V. V.; Bochkova, M. S.; Shardina, K. Yu.; Uzhviyuk, S. V.; Khramtsov, P. V.; Rayev, M. B.; Zamorina, S. A.
- Abstract
The effect of graphene oxide (GO) nanoparticles of 100–200 nm in size coated with linear (LP-GO) and branched (BP-GO) polyethylene glycol at concentrations of 5 and 25 μg/mL on the metabolism of Jurkat tumor cells was studied. It was found that LP-GO nanoparticles at a concentration of 25 μg/mL can enhance basal glycolysis of Jurkat T-lymphocyte tumor cell line cells, while LP-GO and BP-GO at the same concentration can reduce the indicators of compensatory glycolysis. Despite this, GO nanoparticles coated with linear and branched PEG at a concentration of 5 μg/mL do not have pronounced effects on oxidative phosphorylation and glycolysis of Jurkat cells and could therefore be safe for activated T cells.
- Subjects
GRAPHENE oxide; CELL metabolism; GLYCOLYSIS; NANOPARTICLES; POLYETHYLENE glycol; OXIDATIVE phosphorylation
- Publication
Doklady Biochemistry & Biophysics, 2023, Vol 512, Issue 1, p288
- ISSN
1607-6729
- Publication type
Article
- DOI
10.1134/S1607672923700473