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- Title
Alkyl Carbazates for Electrochemical Deoxygenative Functionalization of Heteroarenes.
- Authors
Gao, Yongyuan; Wu, Zhengguang; Yu, Lei; Wang, Yi; Pan, Yi
- Abstract
The C−O bond cleavage for activation of alcohols is synthetically useful and practically challenging. This work describes carbazate as a new type of electrochemically activated alkylating agent derived from ubiquitous alcohols for direct functionalization of heteroarenes under mild electrolytic conditions. The simple undivided cell at low oxidative potentials with carbon/platinum electrode set‐ups offers excellent substrate tolerance, affording a variety of primary, secondary and tertiary alkyl‐decorated heterocycles in good chemical yields. Furthermore, the mechanism for this electrochemical deoxyalkylation reaction has been investigated.
- Subjects
HETEROARENES; CHEMICAL yield; PLATINUM electrodes; SCISSION (Chemistry); HETEROCYCLIC compounds; ALKYLATING agents
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 27, p10951
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202001571