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- Title
Polymorphism of l‐Tryptophan.
- Authors
Al Rahal, Okba; Hughes, Colan E.; Williams, P. Andrew; Logsdail, Andrew J.; Diskin‐Posner, Yael; Harris, Kenneth D. M.
- Abstract
A new polymorph of l‐tryptophan was prepared through crystallization from the gas phase, with structure determination carried out directly from powder XRD data augmented by periodic DFT‐D calculations. The new polymorph (denoted β) and the previously reported polymorph (denoted α) are both based on alternating hydrophilic and hydrophobic layers, but with substantially different hydrogen‐bonding arrangements. The β polymorph exhibits the energetically favourable l2‐l2 hydrogen‐bonding arrangement, which is unprecedented for amino acids with aromatic side chains. The specific molecular conformations adopted in the β polymorph facilitate this hydrogen‐bonding scheme while avoiding steric conflict of the side chains.
- Subjects
MOLECULAR conformation; AMINO acids; TRYPTOPHAN
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 52, p18964
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201908247