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- Title
Light‐Addressable Ion Sensing for Real‐Time Monitoring of Extracellular Potassium.
- Authors
Yang, Ying; Cuartero, Maria; Gonçales, Vinicius Romero; Gooding, J. Justin; Bakker, Eric
- Abstract
We report here on a light addressable potassium (K+) sensor where light illumination of a semiconducting silicon electrode substrate results in a localized activation of the faradaic electrochemistry at the illuminated spot. This allows one, by electrochemical control, to oxidize surface bound ferrocene moieties that in turn trigger K+ transfer from the overlaid K+‐selective film to the solution phase. The resulting voltammetric response is shown to be K+‐selective, where peak position is a direct function of K+ activity at the surface of electrode. This concept was used to measure extracellular K+ concentration changes by stimulating living breast cancer cells. The associated decrease of intracellular K+ level was confirmed with a fluorescent K+ indicator. In contrast to light addressable potentiometry, the approach introduced here relies on dynamic electrochemistry and may be performed in tandem with other electrochemical analysis when studying biological events on the electrode.
- Subjects
POTASSIUM ions; ELECTROCHEMISTRY; BREAST cancer; POTENTIOMETRY; VOLTAMMETRY
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 51, p17043
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201811268