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- Title
Stereoselective Synthesis of Highly Substituted Tetrahydrofurans through Diverted Carbene OH Insertion Reaction.
- Authors
Nicolle, Simon M.; Lewis, William; Hayes, Christopher J.; Moody, Christopher J.
- Abstract
Copper- or rhodium-catalyzed reactions of diazocarbonyl compounds with β-hydroxyketones give highly substituted tetrahydrofurans with excellent diastereoselectivity. Under mild conditions, the single-step process starts as a carbene OH insertion reaction, but is diverted by an intramolecular aldol reaction.
- Subjects
TETRAHYDROFURAN; STEREOSELECTIVE reactions; CHEMICAL synthesis; CARBENES; CHEMICAL reactions
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 29, p8605
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201502484