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- Title
Highly Regio- and Enantioselective Synthesis of γ,δ-Unsaturated Amido Esters by Catalytic Hydrogenation of Conjugated Enamides.
- Authors
Gao, Min; Meng, Jing-jing; Lv, Hui; Zhang, Xumu
- Abstract
An efficient and highly regio- and enantioselective catalytic asymmetric hydrogenation of α,γ-dienamido esters to γ,δ-unsaturated amido esters has been achieved using Rh/TangPhos as the catalyst. A series of γ,δ-unsaturated amido acids were furnished in excellent yields with up to 99 % ee. This effective methodology was applied in the asymmetric synthesis of key intermediate of Ramipril, an ACE inhibitor.
- Subjects
CHEMICAL synthesis; ESTERS; HYDROGENATION; REGIOSELECTIVITY (Chemistry); ENANTIOSELECTIVE catalysis; ASYMMETRIC synthesis; RHODIUM catalysts; ACE inhibitors
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 6, p1905
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201410213