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- Title
Safety of quetiapine fumarate extended release in the treatment of Korean patients with acute schizophrenia.
- Authors
Lee, Jung-Goo; Lee, Jong-Il; Kim, Yang-Tae; Kim, Chul-Eung; Kim, Chang-Yoon; Yoon, Jin-Sang; Yoo, So-Young; Kim, Young-Hoon
- Abstract
Introduction The aim of this study was to evaluate the efficacy and safety of quetiapine fumarate extended release (XR) in the treatment of Korean subjects with acute schizophrenia. Methods This was an 8-week, multi-center, open-label, non-comparative study to evaluate the efficacy and safety of quetiapine fumarate XR at a daily dose of 400-800 mg. Changes in total scores on the Positive and Negative Syndrome Scale (PANSS) from baseline to week 8 were analyzed to evaluate the efficacy of quetiapine XR. Additionally, the Clinical Global Impression scale and the Montgomery-Åsberg Depression Rating Scale were administered. Results The mean change in PANSS total scores was −26.8, and the mean PANSS total score at the endpoint was significantly lower than that at baseline. The mean PANSS positive score, negative score, and general score showed statistically significant reductions at the end of the study. Statistically significant changes were also observed in Clinical Global Impression-Severity and Montgomery-Åsberg Depression Rating Scale scores. The most common treatment-related adverse events in the group receiving quetiapine XR were sedation (10.6%) and constipation (9.6%). Conclusions In this study of Korean patients with acute schizophrenia, quetiapine XR showed clinical efficacy and relatively good tolerability. Copyright © 2012 John Wiley & Sons, Ltd.
- Subjects
SOUTH Korea; QUETIAPINE; SCHIZOPHRENIA treatment; MENTAL illness treatment; MENTAL depression; DRUG efficacy; KOREANS
- Publication
Human Psychopharmacology: Clinical & Experimental, 2012, Vol 27, Issue 4, p403
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/hup.2241