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- Title
N<sup>G</sup>-Nitro-L-Arginine-Methyl-Ester Protects against Ischaemia-Induced Biochemical Changes and Hippocampal Neurodegeneration in the Gerbil.
- Authors
Caldwell, Maeve; O'Neill, Michael; Earley, Bernadette; Leonard, B. E.
- Abstract
To assess the effects of the nitric oxide inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on behavioural, biochemical and histological changes following global ischaemia, the Mongolian gerbil was used. Ischaemia was induced by bilateral carotid occlusion (BCO) for 5 min. NG-nitro-L-arginine methyl ester was administered i.p. at 10 mg/kg 30 min, 6, 24, and 48 h after surgery. Results indicated that 5 min BCO caused a large increase in home cage activity. NG-nitro-L-arginine methyl ester caused some attenuation in this hyperactivity. The activity of nitric oxide synthase (NOS) was increased in the cerebellum, brain stem, striatum, cerebral cortex and hippocampus of 5-min bilateral carotid occluded animals. NG-nitro-L-arginine methyl ester reversed the increase in nitric oxide synthase activity in all brain regions. Extensive neuronal death was observed in the CA1 layer of the hippocampus in 5-min BCO animals 96 h after surgery. NG-nitro-L-arginine methyl ester significantly protected against the neuronal death of cells in the CA1 layer.
- Subjects
NEURODEGENERATION; AMINO acids; ARGININE; ENZYME inhibitors; MONGOLIAN gerbil; PHARMACOLOGY
- Publication
Human Psychopharmacology: Clinical & Experimental, 1996, Vol 11, Issue 4, p299
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/(SICI)1099-1077(199607)11:4<299::AID-HUP772>3.0.CO;2-E