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- Title
Detection of protective antibody titers against feline panleukopenia virus, feline herpesvirus-1, and feline calicivirus in shelter cats using a point-of-care ELISA
- Authors
DiGangi, Brian A.; Gray, Lauren K.; Levy, Julie K.; Dubovi, Edward J.; Tucker, Sylvia J.
- Abstract
Serum antibody titers are a useful measurement of protection against infection (feline panleukopenia virus [FPV]) or clinical disease (feline herpesvirus-1 [FHV] and feline calicivirus [FCV]), and their determination has been recommended as part of disease outbreak management in animal shelters. The objective of this study was to determine the sensitivity, specificity, and inter-observer and inter-assay agreement of two semi-quantitative point-of-care assays for the detection of protective antibody titers (PAT) against FPV, FHV and FCV in shelter cats. Low sensitivity for FPV antibodies (28%) rendered a canine point-of-care assay inappropriate for use in cats. The feline point-of-care assay also had low sensitivity (49%) and low negative predictive value (74%) for FPV PAT detection, but was highly accurate in the assessment of FHV and FCV PAT. Improvements in accuracy and repeatability of FPV PAT determination could make this tool a valuable component of a disease outbreak response in animal shelters.
- Subjects
VIRUS diseases; IMMUNOGLOBULINS; ENZYME-linked immunosorbent assay; POINT-of-care testing; SERUM; PANDEMICS; ANIMAL shelters; SENSITIVITY &; specificity (Statistics); CAT diseases
- Publication
Journal of Feline Medicine & Surgery, 2011, Vol 13, Issue 12, p912
- ISSN
1098-612X
- Publication type
Article
- DOI
10.1016/j.jfms.2011.07.009