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- Title
Anatomical Road Mapping Using CT and MR Enterography for Ultrasound Molecular Imaging of Small Bowel Inflammation in Swine.
- Authors
Wang, Huaijun; Felt, Stephen A.; Guracar, Ismayil; Taviani, Valentina; Zhou, Jianhua; Sigrist, Rosa Maria Silveira; Zhang, Huiping; Liau, Joy; Vilches-Moure, José G.; Tian, Lu; Saenz, Yamil; Bettinger, Thierry; Hargreaves, Brian A.; Lutz, Amelie M.; Willmann, Jürgen K.
- Abstract
<bold>Objectives: </bold>To evaluate the feasibility and time saving of fusing CT and MR enterography with ultrasound for ultrasound molecular imaging (USMI) of inflammation in an acute small bowel inflammation of swine.<bold>Methods: </bold>Nine swine with ileitis were scanned with either CT (n = 3) or MR (n = 6) enterography. Imaging times to load CT/MR images onto a clinical ultrasound machine, fuse them to ultrasound with an anatomical landmark-based approach, and identify ileitis were compared to the imaging times without anatomical road mapping. Inflammation was then assessed by USMI using dual selectin-targeted (MBSelectin) and control (MBControl) contrast agents in diseased and healthy control bowel segments, followed by ex vivo histology.<bold>Results: </bold>Cross-sectional image fusion with ultrasound was feasible with an alignment error of 13.9 ± 9.7 mm. Anatomical road mapping significantly reduced (P < 0.001) scanning times by 40%. Localising ileitis was achieved within 1.0 min. Subsequently performed USMI demonstrated significantly (P < 0.001) higher imaging signal using MBSelectin compared to MBControl and histology confirmed a significantly higher inflammation score (P = 0.006) and P- and E-selectin expression (P ≤ 0.02) in inflamed vs. healthy bowel.<bold>Conclusions: </bold>Fusion of CT and MR enterography data sets with ultrasound in real time is feasible and allows rapid anatomical localisation of ileitis for subsequent quantification of inflammation using USMI.<bold>Key Points: </bold>• Real-time fusion of CT/MRI with ultrasound to localise ileitis is feasible. • Anatomical road mapping using CT/MRI significantly decreases the scanning time for USMI. • USMI allows quantification of inflammation in swine, verified with ex vivo histology.
- Subjects
ULTRASONIC imaging; MEDICAL technology; CHRONIC pain; INFLAMMATORY bowel diseases; COMPUTED tomography
- Publication
European Radiology, 2018, Vol 28, Issue 5, p2068
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-017-5148-6