We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Amide proton transfer imaging for differentiation of benign and atypical meningiomas.
- Authors
Joo, Bio; Han, Kyunghwa; Choi, Yoon Seong; Lee, Seung-Koo; Ahn, Sung Soo; Chang, Jong Hee; Kang, Seok-Gu; Kim, Se Hoon; Zhou, Jinyuan
- Abstract
<bold>Purpose: </bold>To investigate the difference in amide proton transfer (APT)-weighted signals between benign and atypical meningiomas and determine the value of APT imaging for differentiating the two.<bold>Methods: </bold>Fifty-seven patients with pathologically diagnosed meningiomas (benign, 44; atypical, 13), who underwent preoperative MRI with APT imaging between December 2014 and August 2016 were included. We compared normalised magnetisation transfer ratio asymmetry (nMTR asym ) values between benign and atypical meningiomas on APT-weighted images. Conventional MRI features were qualitatively assessed. Both imaging features were evaluated by multivariable logistic regression analysis. The discriminative value of MRI with and without nMTR asym was evaluated.<bold>Results: </bold>The nMTR asym of atypical meningiomas was significantly greater than that of benign meningiomas (2.46% vs. 1.67%; P < 0.001). In conventional MR images, benign and atypical meningiomas exhibited significant differences in maximum tumour diameter, non-skull base location, and heterogeneous enhancement. On multivariable logistic regression analysis, high nMTR asym was an independent predictor of atypical meningiomas (adjusted OR, 11.227; P = 0.014). The diagnostic performance of MRI improved with nMTR asym for predicting atypical meningiomas.<bold>Conclusion: </bold>Atypical meningiomas exhibited significantly higher APT-weighted signal intensities than benign meningiomas. The discriminative value of conventional MRI improved significantly when combined with APT imaging for diagnosis of atypical meningioma.<bold>Key Points: </bold>• APT imaging is useful for differentiating between atypical and benign meningiomas. • Atypical meningiomas exhibited high APT-weighted signal intensity than benign meningiomas. • The diagnostic performance of MRI improved with nMTR asym for predicting atypical meningiomas.
- Subjects
BENIGN tumors; MENINGIOMA; MAGNETIC resonance imaging; TUMOR growth; TUMOR grading; THERAPEUTICS
- Publication
European Radiology, 2018, Vol 28, Issue 1, p331
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-017-4962-1