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- Title
Effective of metronidazole to bacterial flora in vagina and the impact of microbes on live birth rate during intracytoplasmic sperm injection (ICSI).
- Authors
Selim, Samy; El Alfy, Sahar; Aziz, Mohamed; Mohamed, Hussein; Alasbahi, Amin
- Abstract
Purpose: The aim of this study was to investigate the impact of bacterial vaginal flora on life-birth rate during ICSI and influence of metronidazole as antibiotic treatment course before ICSI. Method: We enrolled 71 women who were undergoing ICSI. At embryo transfer (ET), all of the women had quantitative vaginal culture, ET catheter-tip culture, and vaginal Gram stain scored for bacterial vaginosis. Results: The overall live birth rate (LBR) was 36.6% (26/71), and the rate of early pregnancy loss was 13% (4/30). In women with bacterial vaginosis, intermediate flora and normal flora, the conception rates were 35% (9/26), 42% (14/33) and 58% (7/12), respectively ( p = 0.06 for trend). Metronidazole effect to bacterial flora in vaginal. The predominant species isolated from the tip of the embryo transfer catheter in negative pregnancy was Staphylococcus epidermidis (7 vs. 15.2%), and Streptococcus viridians (11 vs. 24%). Conclusions: Woman with bacterial vaginosis and with a decreased vaginal concentration of hydrogen peroxide-producing lactobacilli may have decreased conception rates and increased rates of failed pregnancy. A larger prospective treatment trial designed to evaluate the impact on ICSI outcomes of optimizing the vaginal flora prior to ICSI may be warranted.
- Subjects
VAGINAL disease treatment; METRONIDAZOLE; EMBRYO transfer; ANTI-infective agents; BACTERIAL diseases; DRUG resistance in microorganisms; BIRTH rate
- Publication
Archives of Gynecology & Obstetrics, 2011, Vol 284, Issue 6, p1449
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-011-1857-2