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- Title
Maternal intake of fatty acids and their food sources during lactation and the risk of preclinical and clinical type 1 diabetes in the offspring.
- Authors
Niinistö, S.; Takkinen, H.-M.; Uusitalo, L.; Rautanen, J.; Vainio, N.; Ahonen, S.; Nevalainen, J.; Kenward, M.; Lumia, M.; Simell, O.; Veijola, R.; Ilonen, J.; Knip, M.; Virtanen, S.
- Abstract
Aims: We examined maternal dietary intake of fatty acids and foods which are sources of fatty acids during lactation and whether they are associated with the risk of preclinical and clinical type 1 diabetes in the offspring. Methods: The subjects comprised a cohort of 2,939 mother-child pairs from the prospective Type 1 Diabetes Prediction and Prevention Study. Composition of maternal diet during the third month of lactation was assessed by a validated food frequency questionnaire. Among the children with HLA-conferred susceptibility to type 1 diabetes, 172 developed preclinical and 81 clinical diabetes. Average follow-up for preclinical type 1 diabetes was 7.5 years (range 0.2-14.0 years) and for clinical type 1 diabetes 7.7 years (0.2-14.0 years). Results: Maternal intake of fatty acids during lactation was not associated with the risk of type 1 diabetes in the offspring. After adjusting for putative confounders, maternal total consumption of red meat and meat products during lactation was associated both with increased risk for preclinical [hazard ratio (HR) 1.19, 95 % CI 1.02-1.40, p = 0.038] and clinical type 1 diabetes (HR 1.27, 95 % CI 1.06-1.52, p = 0.025). In particular, consumption of processed meat products showed an association with increased risk for type 1 diabetes (HR 1.23, 95 % CI 1.02-1.48, p = 0.045). Maternal use of vegetable oils was associated with increased risk for preclinical type 1 diabetes (HR 1.21, 95 % CI 1.03-1.41, p = 0.023). Conclusions: Maternal consumption of red meat, especially processed meat, during lactation may increase the risk of type 1 diabetes.
- Subjects
TYPE 1 diabetes; FATTY acid content of food; FOOD consumption; LACTATION; MOTHER-child relationship; FOLLOW-up studies (Medicine); HEALTH; DIABETES risk factors
- Publication
Acta Diabetologica, 2015, Vol 52, Issue 4, p763
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-014-0673-0