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- Title
Neurotoxicity associated with adenine arabinoside monophosphate in the treatment of chronic hepatitis B virus infection.
- Authors
Lok, A. S. F.; Wilson, L. A.; Thomas, H. C.; Lok, A S
- Abstract
Thirty-one patients with chronic HBV infection were randomized to receive a short or long course of ARA-AMP. Fifteen completed a 4 week course of treatment and 16 completed longer courses varying from 7 to 12 weeks. Eighteen patients did not experience any neurological side effects. Six patients had myalgia. This was not associated with any neurological deficit. Seven patients developed a sensory neuropathy with distressing pain and dysesthesiae in the feet and abnormalities in nerve conduction. The development of neurotoxicity was related to a long duration of treatment and a correspondingly higher total dose but there was no association with the severity of liver disease.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1984, Vol 14, Issue 1, p93
- ISSN
0305-7453
- Publication type
journal article