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- Title
Bactericidal effect against Escherichia coli of nalidixic acid and four structurally related compounds.
- Authors
Stevens, P. J. E.; Stevens, P J
- Abstract
The bactericidal action of nalidixic acid (NAL) and four structurally related compounds, oxolinic acid, 17563, 17607 and 17665, was examined in NAL-sensitive and -resistant strains of . In the NAL-sensitive strain, NAL, 17563 and 17665 were bactericidal and 17607 was bacteriostatic, whereas in the NAL-resistant strain oxolinic acid was the only bactericidal compound. Cell death occurred at concentrations which inhibited DNA biosynthesis whilst having little effect on RNA and protein syntheses. Cell stasis occurred at concentrations which inhibited all three macromolecular processes.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1980, Vol 6, Issue 4, p535
- ISSN
0305-7453
- Publication type
journal article