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- Title
Vaccines: TBK1 mediates DNA vaccine immunogenicity.
- Authors
Tufet, Marta
- Abstract
The article discusses a study which reveals that TANK-binding kinase 1 mediates the adjuvant effects of DNA vaccines and that this effect occurs independently of the Toll-like receptor signaling pathway. The study showed that signaling by type I interferons (IFN) was indispensable for the induction of DNA vaccine immunogenicity. Mice that lacked type-I-IFN-mediated signaling could not elicit strong T- and B-cell responses to various antigens after immunization with the proper DNA vaccine.
- Subjects
DNA vaccines; VACCINATION; INTERFERONS; ANTINEOPLASTIC agents; T cells; B cells; IMMUNOGENETICS
- Publication
Nature Reviews Immunology, 2008, Vol 8, Issue 3, p164
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri2287