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- Title
Detection of a circulating inhibitor of the Na<sup>+</sup>-K<sup>+</sup>-Cl<sup>−</sup> cotransport system in plasma and urine after high salt intake<sup>*</sup>.
- Authors
Parés, Inmaculada; de la Sierra, Alejandro; Coca, Antonio; del Mar Lluch, María; Urbano-Márquez, Alvaro; Garay, Ricardo
- Abstract
The aim of the study was to detect the presence of an endogenous Na+-K+-Cl− cotransport inhibitor factor in plasma and urine from salt-loaded subjects. Twenty-six essential hypertensive patients (13 men, 13 women) and 6 normotensive controls (2 men, 4 women) received a diet containing 260 mmol/day of NaCl tablets for 7 days. Human erythrocytes from healthy blood donors (using bumetanide-stimulated Li+ efflux) were used to test the inhibition of Na+-K+-Cl− cotransport by different plasma and urine concentrations collected the last day of the salt-loaded period. The addition of plasma and urine from salt-loaded subjects significantly inhibited erythrocyte Na+-K+-Cl− cotransport (P < .001). No differences were observed between hypertensive patients and normotensive controls. These results provide evidence of an Na+-K+-Cl− cotransport inhibitor factor in plasma and urine from salt-loaded humans, in concordance with previous reports in salt-loaded rats.
- Publication
American Journal of Hypertension, 1995, Vol 8, Issue 10, p965
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/0895-7061(95)00215-4