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- Title
Investigation into a high-p,T,c continuous flow synthesis of myristyl-γ-picolinium chloride (MGPC) – a preservative in pharmaceutical formulations.
- Authors
Veeramani, Karuna; Shinde, Manish; Eda, Vishnuvardhana Vema Reddy; Peraka, Swamy; Mohan, Saranya; Bandichhor, Rakeshwar; Oruganti, Srinivas
- Abstract
Myristyl-γ-picolinium chloride (MGPC) is an alkyl pyridine quaternary ammonium salt and a popular preservative in injectables such as Depo-Medrol (Methylprednisolone acetate). Herein we describe a successful high-p,T,c chemical intensification of MGPC synthesis from neat myristyl chloride and γ-picoline in continuous flow. The process is atom economical, scalable with low reactor footprint and under optimized conditions, consistently affords MGPC in 45 min (instead of 8–12 h reported in literature for a conventional batch process) with excellent yield (> 90%) and purity (> 99%).
- Subjects
DRUG additives; QUATERNARY ammonium salts; CHLORIDES; BATCH processing
- Publication
Journal of Flow Chemistry, 2024, Vol 14, Issue 2, p481
- ISSN
2062-249X
- Publication type
Article
- DOI
10.1007/s41981-024-00309-0