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- Title
肥厚型心肌病患者认知功能障碍的发生及影响因素分析.
- Authors
王炫颖; 王博; 张娟; 常康; 杨倩利; 王静; 赵雪丽; 刘之荣; 刘丽文
- Abstract
Objective: To describe the occurrence of cognitive impairment in hypertrophic cardiomyopathy (HCM) patients and explore possible influencing factors associated with cognitive impairment. Methods: 198 patients with HCM, who were admitted in the department of ultrasound, Xijing Hospital of Air Force Medical University from April 2018 to July 2019, were collected. Both Montreal Cognitive Assessment (MoCA) test and education years were considered to assess cognitive function of these patients. The cutoff score for cognitive impairment to the present study were 14 for illiterate patients, 19 for patients with 1-6 years of education, and 24 for patients with 7 or more years of education. And according to this criterion, HCM patients were divided into cognitive impairment group (n=37) and normal cognitive function group (n=161). Demographic data and clinical characteristics, life style and history of diseases, echocardiography and cognitive assessment were collected and compared between two groups. Multivariate logistic regression analysis was used to assess the possible risk factors for cognitive impairment in HCMpatients. Results: The incidence of cognitive impairment in HCMpatients was 18.7 %. Patients in cognitive impairment group were older in age (P<0.05), had shorter years of education (P<0.05), poorer cardiac function and diastolic function in left ventricular (P<0.05) and significantly higher pressure of provoked left ventricular outflow tract pressure gradient (LVOT-PG, P<0.05). Besides, patients in cognitive impairment group had lower MoCA score (P<0.05), especially a poorer performance in visual space and executive function and delayed recall (P<0.05). The results of multivariate logistic regression analysis showed that after adjusting for age (OR=14.435, 95 %OR 4.476-46.550; P<0.001) and years of education (OR=5.274, 95 %OR 2.024-13.744; P=0.001), LVOT-PG (OR=3.844, 95 %CI: 1.551-9.524; P=0.004) was an independent risk factor for cognitive impairment in HCMpatients. Conclusion: LVOT-PG can increase the risk of cognitive impairment in patients with HCM. In the clinic, it is necessary to pay attention to the change of LVOT-PG in HCM patients for early prevention of the occurrence and progression of cognitive impairment.
- Subjects
COGNITION disorders; VENTRICULAR outflow obstruction; MONTREAL Cognitive Assessment; LOGISTIC regression analysis; HYPERTROPHIC cardiomyopathy; FUNCTION spaces
- Publication
Progress in Modern Biomedicine, 2020, Vol 20, Issue 9, p1462
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2020.08.013