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- Title
孟鲁司特钠联合左卡巴斯汀鼻喷剂治疗小儿过敏性鼻炎的疗效评价 及对血清ECP、EOS 及CRP 水平的影响*
- Authors
林小燕; 范穗强; 杜钢; 孟春想; 杜晶
- Abstract
To explore the efficacy of monclulast sodium combined with levorabastine nasal spray in the treatment of allergic rhinitis in children and the effects on serum levels of eosinophil cationic protein (ECP), eosinophil (EOS) and c-reactive protein (CRP). 151 cases of children with allergic rhinitis who treated from July 2016 to July 2018 in our hospital, according to random number table method thoese childre were divided into 69 control groups and 82 observation groups, the control group was treated with levocarbastine nasal spray, and the observation group was treated with montelukast sodium on the basis of the control group.then clinical curative effect, the symptoms and signs scores, the quality of life score, serum levels of ECP, EOS and CRP, total immunoglobulin E (TIgE) and specific immunoglobulin E (SIgE) before and after the treatment, and adverse reactions occur in both group were compared. The total effective rate in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). Before treatment, the scores of symptoms and signs, quality of life, serum levels of ECP, EOS and CRP, total immunoglobulin E (TIgE) and specific immunoglobulin E (SIgE) showed no significant difference between the two groups (P>0.05). After treatment, the above indicators in both groups were decreased, and the observation group was lower than the control group, and the difference was statistically significant (all P<0.05). Both groups had gastrointestinal reactions, dry mouth, and headache, and there was no statistical difference in the incidence of total adverse reactions between the two groups (P>0.05). Montelukast sodium combined with levorabastine nasal spray is safe and effective in the treatment of allergic rhinitis in children, which can reduce serum levels of ECP, EOS and CRP and promote the recovery of children.
- Subjects
BASIC proteins; IMMUNOGLOBULIN E; INTRANASAL medication; C-reactive protein; SYMPTOMS; ALLERGIC rhinitis
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 17, p3263
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.17.012