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- Title
小剂量纳洛酮硬膜外应用对胃癌术后芬太尼静脉自控镇痛效果及胃肠功能的影响
- Authors
陈萍; 韩卫东; 李贺; 肖思; 张怀奇; 李琼
- Abstract
Objective: To explore the effects of small dose ofnaloxone epidural application on fentanyl intravenous analgesia and gastrointestinal function of patients after surgery for gastric cancer.Methods:110 cases of patients with gastric cancer in our hospital from July 2010 to July 2015 were selected as the research subject,who were randomly devided into experimental group and control group with 55 cases in each.The patients in the two groups were treated with radical resection of tumor and fentanyl intravenous analgesia,and the experimental group were injected with small dose of naloxone into the epidural space,and the control group were injected with equal amount of saline.The pain degree of two groups at different time points(4 h,8 h,12 h,24 h)were evaluated.The recovery time of bowel sound,anal exhaust time,defecation time,recovery time of gastric motility,drug consumption of analgesic pump and the rates of nausea,complications of patients in the two groups were observed and compared.Results:The pain score in the experimental group postoperative 4 h was significantly lower than that in the control group (P<0.05),of which the two groups were significantly increased postoperative 8 h and 12 h (P<0.05),but the pain scores in the experimental group were far lower than those of the control group (P<0.05).There was no significant difference in the pain scores of the experimental group postoperative 12 h with that postoperative 24h(P>0.05),of which the control group was significantly different comparing with postoperative 12 h (P<0.05).The recovery time of bowel sound,anal exhaust time,defecation time,recovery time of gastric motility,drug consumption of analgesic pump and dosage of fentanyl in the experimental group were significantly lower than those in the control group (P<0.05).The total incidence of complications in the experimental group (7.27%)was much lower than that in the control group (23.64%),and the difference was statistically significant(P<0.05).Conclusion:It is effective to reduce the pain of patients,reduce the incidence of complications and promote the recovery of gastrointestinal function by small dose ofnaloxone epidural application,and it is worth to be popularized in clinical practice.
- Publication
Progress in Modern Biomedicine, 2017, Vol 17, Issue 3, p513
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2017.03.029