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- Title
Application and Progress of Carnosine in Treatment of Vascular Dementia.
- Authors
MA Jing; CHEN Ting; ZHANG Jin-lian; XUA-jing; LIU Yan
- Abstract
Vascular dementia (VaD), which is recognized as the second most prevalent type of dementia is often observed in patients with hypertension or atherosclerosis. Its characteristic damage involves progressive demyelination, cognitive impairment and white matter rarefaction. However, pathogenetic mechanisms are far from understood, with currently no effective agents to prevent or reverse its progression. Therefore, it's necessary to develop new agents for treatment or prevention of VaD. Carnosine (ß-alanyl-L-histidine) is a natural dipeptide that is highly expressed in the central nervous system, and can easily enter the brain from the periphery. Carnosine can converse to histidine and then histamine. Carnosine had a protective effect in VaD, which did not involve the carnosine-histidine-histamine metabolic pathway, but may be due to an inhibition of excitatory amino acid, reactive oxygen specie generation, glia activation and myelin degeneration. These data suggest that carnosine may have potential value for the therapeutic treatment in VaD. This review focuses on the role of carnosine in vascular dementia.
- Publication
Progress in Modern Biomedicine, 2015, Vol 15, Issue 4, p740
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2015.04.037