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- Title
The Placebo Response in Adult ADHD as Objectively Assessed by the TOVA Continuous Performance Test.
- Authors
Rotem, Ann; Ben-Sheetrit, Joseph; Newcorn, Jeffrey; Danieli, Yaron; Peskin, Miriam; Golubchik, Pavel; Ben-Hayun, Rachel; Weizman, Abraham; Manor, Iris
- Abstract
Objective: We compared the placebo response (PR) as measured by the Test of Variables of Attention (TOVA) and the Conners' Adult ADHD Rating Scale (CAARS) scores. Method: A retrospective data analysis from a double-blind placebo-controlled study of metadoxine-ER in adults with ADHD. An additional database was used for comparison to TOVA response after methylphenidate challenge (TOVA-MPH-R). Results: PR was highest when calculated from the TOVA-Attention Composite Score (ACS). The PR showed significantly fewer variables improving concomitantly compared with MPH-R. The most prominent correlation between the CAARS-PR and the TOVA-PR was in the Omissions score (p = .032), which was age-dependent (b = .0007, p <.001). Discussion: TOVA-PR has an index-specific profile compared with CAARS-PR and TOVA-MPH-R. The partial correlation of TOVA-PR with CAARS-PR suggests that a composite score of TOVA specific indices and CAARS could have a synergic impact to improve the reliability of the response assessment in adult ADHD.
- Subjects
ATTENTION-deficit hyperactivity disorder; CONTINUOUS performance test; METHYLPHENIDATE; DATA analysis; STATISTICAL correlation
- Publication
Journal of Attention Disorders, 2021, Vol 25, Issue 9, p1311
- ISSN
1087-0547
- Publication type
journal article
- DOI
10.1177/1087054719897819