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- Title
HRCT features of surgically resected invasive mucinous adenocarcinoma associated with interstitial pneumonia.
- Authors
Miyamoto, Atsushi; Kurosaki, Atsuko; Fujii, Takeshi; Kishi, Kazuma; Homma, Sakae
- Abstract
Background and objective Lung cancer is prevalent among patients with interstitial pneumonia ( IP). HRCT findings mucinous adenocarcinoma in patients with IP have not been described. Methods In 112 consecutive patients with 120 surgically resected IP-associated lung cancers, 42 patients had pathologically proven invasive adenocarcinoma ( IA). A total of 14 out of 42 patients (10 men, 4 women, mean age, 68.4 years) had invasive mucinous adenocarcinoma. We reviewed the patients' medical records and HRCT scans. Results Invasive mucinous adenocarcinoma were most commonly associated with idiopathic IP ( n = 13) affecting the lower lobe adjacent to a fibrocystic changes. In 11 patients with invasive mucinous adenocarcinoma or other types of IA, the tumour was adjacent to a fibrocystic lesion. In invasive mucinous adenocarcinoma, malignant signs included lobulation ( n = 11), spiculation ( n = 9), vascular convergence ( n = 10) and pleural indentation ( n = 2). Characteristic findings of mucinous adenocarcinoma (i.e. vague margins ( n = 10), lobular-bounded margins ( n = 11), air bronchogram ( n = 11) and bubble-like low attenuation ( n = 8)) were more common in invasive mucinous adenocarcinoma than in other IA types. All invasive mucinous adenocarcinoma tumours ( n = 11) were closely associated with fibrosis. Conclusion Mixed ground-glass opacity and consolidation adjacent to a fibrocystic lesion with malignant signs and characteristic features of mucinous adenocarcinoma indicate malignancy.
- Subjects
MUCINOUS adenocarcinoma; PULMONARY fibrosis; COMPUTED tomography; LUNG cancer; MEDICAL records; PATIENTS
- Publication
Respirology, 2017, Vol 22, Issue 4, p735
- ISSN
1323-7799
- Publication type
Article
- DOI
10.1111/resp.12947