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- Title
Intraepithelial carcinoma arising in an endodermal cyst of the posterior fossa.
- Authors
Monaco, Roberto; Boscaino, Amedeo; Di Blasi, Arturo; D'Antonio, Antonio; Profeta, Giovanni; De Falco, Raffaele; Nappi, Oscar
- Abstract
Endodermal cysts of the central neuraxis are benign, non-neoplastic epithelium-lined cysts arising from endodermal tissue that have been displaced early in fetal life. Intracranial endodermal cysts are rare and usually located in the posterior fossa. The present study involves a 36-year-old man with a typical epithelial cyst in the posterior fossa. Microscopically, the cyst has a simple columnar epithelium with mucus-producing cells, containing an area composed of dysplastic epithelium with evidence of an intraepithelial carcinoma. The atypical cells have a high proliferative fraction demonstrated by Ki-67 immunostain. Based on these findings, the authors view this case as evidence of a malignant transformation of a classic endodermal cyst. The clinicopathologic features and a review of the literature are discussed.
- Subjects
CYSTS (Pathology); BRAIN cancer; EPITHELIUM
- Publication
Neuropathology, 2003, Vol 23, Issue 3, p219
- ISSN
0919-6544
- Publication type
Article
- DOI
10.1046/j.1440-1789.2003.00497.x